Like its predecessors, Slime Speedway is based around characters from various Nickelodeon animated series, known as ' Nicktoons', participating in kart races and attempting to defeat their opponents.
It is the third entry in the Nickelodeon Kart Racers series, following Nickelodeon Kart Racers (2018) and Nickelodeon Kart Racers 2: Grand Prix (2020). Nickelodeon Kart Racers 3: Slime Speedway is a racing game developed by Bamtang Games and published by GameMill Entertainment.